Alpha amidating monooxygenase

Our findings have thus defined a novel monooxygenase-based oxygen sensing mechanism that has the capacity to signal changes in oxygen availability to peptidergic pathways.Peptidylglycine alpha-amidating monooxygenase (EC 1.14.17.3) is a multifunctional protein containing 2 enzymes, peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL), that act sequentially to catalyze the alpha-amidation of neuroendocrine peptides. Peptidylglycine alpha-amidating monooxygenase (EC 1.14.17.3) is a multifunctional protein containing 2 enzymes, peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL), that act sequentially to catalyze the alpha-amidation of neuroendocrine peptides. (1990) showed that alternative splicing generates 2 forms of PAM m RNA in humans. (1993) used Southern blot analysis of human placental DNA to demonstrate that PAM is encoded by a single gene. (1992) mapped the human PAM gene to the long arm of chromosome 5. The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known.View entry in original ENZYME format View entry in raw text format (no links) All Uni Prot KB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.Submit a review and receive a US/€18/£15/CAN amazon gift card if you include an image - US/€7/£6/CAN Amazon card for reviews without an image.

Many of the features of PAM expression, processing, and storage that are unique to cardiomyocytes as opposed to endocrine cells are faithfully replicated by primary atrial and ventricular cultures.Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of m RNA for the original gene.The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Chimera RNAi has many advantages over the conventional si RNAs.PAM is required for the biosynthesis of peptides such as Substance P, neuropeptide Y, oxytocin, vasopressin, and calcitonin (3).PAM is highly expressed in tissues that synthesize bioactive peptides, such as the thyroid and pituitary glands.

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